Products
Protein A Resin
Product Introduction
Protein A Captarose HL resin is a chromatography resin specifically designed for large-scale processes. Built on the Captarose HF agarose platform, its highly rigid skeleton and well-defined pore structure deliver exceptional pressure resistance and high flow rate performance. The Protein A ligand has undergone specialized optimization to enhance stability while maintaining high affinity for the Fc region. Produced via recombinant E. coli expression with an animal-free manufacturing process, this affinity chromatography resin exhibits stable physicochemical properties, making it ideal for large-scale industrial production. It serves as an optimal choice for purifying monoclonal antibodies, bispecific antibodies, and Fc-fusion proteins.
Product Highlights
High Binding Capacity
Strong Alkali Resistance
Low Ligand Leakage
High Rigidity, Low Backpressure, High Flow Rate
Storage Condition
20% Ethanol;2-8°C
Technical Parameters
Product Name Protein A Captarose HL
Matrix Highly Rigid Agarose Resin
Average Particle Size 75 µm
Ligand Recombinant Alkali-Resistant Protein A (E. Coli)
Dynamic Binding Capacity ≥55 mg Human IgG/mL Resin
Recommended Flow Rate 100-500 cm/h
Recommended Pressure <0.5 MPa (5 bar)
pH Stability 3-12 (Long-term*); 2-14 (CIP, Short-term*)
Chemical Stability Tolerates 6 M Guanidine Hydrochloride, 8 M Urea, 0.5 M NaOH

Note **: Long-term refers to the pH range where the resin remains stable over extended periods without adversely affecting subsequent performance. Short-term refers to the pH range experienced during resin regeneration, in-place cleaning, and sanitization based on empirical data.

Ordering Information
Product Name Catalog No. Specification
Protein A Captarose HL HC1010001 25 mL
HC1010002 100 mL
HC1010004 1 L
HC1010005 5 L
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