Products
MIX-C Resin
Product Introduction
Mixed-mode chromatography resin represents an advanced class of resins that immobilize multimodal ligands onto a substrate matrix. By enabling multiple types of molecular interactions with target molecules or impurities, this technology achieves superior selectivity and operational flexibility across diverse process conditions, effectively addressing complex separation and purification challenges.
MIX-C Captarose HF is a weak cation exchange mixed-mode chromatography resin that incorporates both ion-exchange groups and benzene rings, unlike conventional weak cation exchange resins. The special functional groups confer novel selectivity to the resin. Its application requires comprehensive consideration of protein hydrophobic and charge properties for effective separation and purification. The resin matrix consists of highly cross-linked agarose with exceptional rigidity, enabling high-flow-rate operations. With stable physicochemical properties, it is well-suited for large-scale industrial production.
Product Highlights
Highly Rigid
High Flow Rate
Uniform Particle Size
Excellent Stability
Superior Reproducibility
Scalable
High Pressure Resistance, Low Back Pressure
Strong Hydrophilicity, Minimal Non-specific Adsorption
High Versatility, Broad Application Scope
Technical Parameters
Product Name MIX-C Captarose HF MIX-C Captarose HR MIX-CH Captarose HF MIX-CL Captarose HF
Matrix Highly Rigid Agarose
Average Particle Size 75 µm 40 µm 75 µm
Ligand Weak Cation Ligand with Mixed Mode
Ion Loading Capacity 70-90 μmol H⁺/mL resin 25-39 μmol H⁺/mL resin 60-100 μmol H⁺/mL resin
Recommended Flow Rate <600 cm/h <300 cm/h <600 cm/h
Recommended Pressure <0.5 MPa (5 bar)
Operating pH Range* 3-12
pH Stability 3-12 (Long-term**); 2-14 (Short-term**)
Chemical Stability Stable in common buffers including 1 M NaCl, 1 M NaOH, 6 M Guanidine Hydrochloride, 8 M Urea, 70% Ethanol, 30% Isopropanol, etc.
Storage Conditions 20% Ethanol; 4-30℃

Note *: Operating pH range refers to the pH range for achieving separation/purification functions while maintaining resin stability.
Note **: Long-term refers to pH range where the resin maintains stability without compromising performance. Short-term refers to pH range for regeneration, in-place cleaning, and sterilization.

Ordering Information
Product Name Catalog No. Specification
MIX-C Captarose HF HC5020001 25 mL
HC5020002 100 mL
HC5020004 1 L
HC5020005 5 L
MIX-C Captarose HR HC5020101 25 mL
HC5020102 100 mL
HC5020104 1 L
HC5020105 5 L
MIX-CH Captarose HF HC5070101 25 mL
HC5070102 100 mL
HC5070104 1 L
HC5070105 5 L
MIX-CL Captarose HF HC5070201 25 mL
HC5070202 100 mL
HC5070204 1 L
HC5070205 5 L
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