Pinshan Biotech - A Supplier of Core Consumables and Solutions for Biopharmaceuticals-Pinshan Biotechnology (Shanghai) Co., Ltd

CulClear®‌ Depth Filtration Production-Scale Filter

Product Introduction

CulClear®‌ Depth Filter is mainly used for step-by-step clarification from the laboratory process development to the commercial production process after upstream cell culture. The main components are cellulose, diatomaceous earth, and positively charged special synthetic resin, which can effectively remove cell debris, host cell protein HCP, DNA, and endotoxin in the culture medium, reduce the turbidity of the customer's feed solution after harvest, and improve the overall performance of downstream processes.

Sample Application

Product Highlights

Simple to Use: A single-use design removes the requirement for intricate cleaning and verification processes.

High Retention Efficiency: Cellulose can efficiently intercept the three-dimensional spatial structure of solid particles and effectively remove cells and cell debris.

High Containment Capacity: Filter aids, diatomaceous earth and positively charged resins can effectively adsorb DNA, HCP and endotoxins.

Efficient Collaboration: Compatible with current mainstream clarifying fixtures and systems.

Small Hold Up Volume: Small cleaning volume after use ensures a high product recovery rate.

Stable Supply: Localized production guarantees reliable and consistent delivery.

Flexible Selection: Offer a diverse range of media series to cater to the practical application needs of customers' process development.

Market Applications

Clarification of CHO cell culture medium and yeast fermentation medium (after centrifugation)

Clarification of vaccine production process

Clarification of serum and blood products

Clarification of plasmid production process (E. coli lysate)

Clarification of lentivirus and adeno-associated virus culture medium

Clarification of enzyme preparation

Technical Parameters

Product Series	Lab Scale	Production Scale
Effective Filtration Area（EFA）	23 cm²	0.11 m²	0.55 m²	1.1 m²
Inlet, Vent, and Outlet Connection	TC25	Flat Seal
Overall Size
-Length-	7.5cm	62cm	62cm	62cm
-Height-	7.5cm	32.5cm	32.5cm	32.5cm
-Thickness-	7.5cm	3.4cm	7.3cm	14cm
Filter Membrane	Cellulose, Filter Aids, and Resins
Support Layer and Cover Plate	Polypropylene (PP)
Joints, Gaskets, and Plugs	Polypropylene (PP)
O-Ring	Silicone Rubber
Maximum Operating Pressure	0.35MPa@25℃
Max Forward Pressure	0.3MPa@25°C
Max Reverse Pressure	0.2MPa@25℃
Tolerance of Autoclave	2 autoclave cycles of 60 minutes at 123℃
Indirect Food Additives	All component materials meet the FDA indirect Food Additive Requirements cited in 21 CFR 177-182
Toxicity	Meet the requirements of USP<88> Biological Reactivity Test for Class VI Plastics
Bacterial Endotoxins	< 0.25EU/mL, utilizing LAL clot test technique
Quality Assurance	This filter has been produced in a factory that follows the ISO9001 quality management system.

Ordering Information

PRODUCT NAME	MEMBRANE AREA	PORE TYPE	PORE SIZE	MEMBRANE GRADE	JOINT	PACKAGE QTY
PSDF =Depth Filter	L23 = 23 cm²	A B C D E F G H I J K L M N O P Q R	0~9	HP	T0=TC25 T1=Flat Seal	1 = 1/Pack 3 = 3 /Pack
	C01 = 0.11 m²
	C05 = 0.55 m²
	C11 = 1.1 m²

Download

CulClear™ Depth Filter Brochure